The NISEC committee reports findings to the Minister of Health, the national Department of Health and the provincial Departments of Health and to the South African Health Products Regulatory Authority (SAHPRA). NISEC adverse event data and final assessments are reported into the WHO so that pooled data from countries can contribute to global monitoring of safety signals. These data are reported via SAHPRA through the global ‘Vigibase’ and ‘Vigiflow’ database systems that are used to track adverse effects related to pharmaceutical and therapeutic treatments.